Institutional Repository of Key Laboratory of Mental Health, CAS
Interaction between job stress, serum BDNF level and the BDNF rs2049046 polymorphism in job burnout | |
He, Shu-Chang1,2; Wu, Shuang1,2; Wang, Chao1,2; Wang, Dong-Mei3,4; Wang, Jiesi3,4; Xu, Hang3,4; Wang, Li3,4; Zhang, Xiang Yang3,4 | |
第一作者 | He, Shu-Chang |
通讯作者邮箱 | shuchangh@pku.edu.cn (s.-c. he), ; zhangxy@psych.ac.cn (x.y. zhang) |
心理所单位排序 | 3 |
摘要 | Background: Some studies have shown that long-term exposure to job stress could result in burnout, and BDNF polymorphism may play an important role in its psychopathological mechanism. However, the inter-relationships between the job-related stress, serum BDNF level, BDNF genotype and job burnout have not been examined. This study was to explore the job stress x BDNF rs2049046 interaction and the role of serum BDNF level in job burnout in a Chinese Han population. Methods: Using a cross-sectional design, 205 healthy subjects were recruited from a public institution in Beijing and assessed for job stress using the House and Rizzo's Work Stress Scale, and job burnout using the Maslach Burnout Inventory (MBI). The BDNF rs2049046 polymorphism was genotyped and serum BDNF (sBDNF) levels were assayed in all of subjects. Results: The correlations between the job stress score and two burnout subscale scores (emotional exhaustion and cynicism) were significant (both p < 0.001), but not with professional efficacy. There were no significant main effects of the BDNF rs2049046 genotype on burnout, and no significant correlation was observed between sBDNF levels and job burnout. However, the interaction between the job stress and the BDNF rs2049046 genotype (F = 2.709, df = 2, 183, p = 0.032) or between the job stress and sBDNF levels on burnout was significant (t = - 2.132, p = 0.035). To be specific, the individuals with the BDNF rs2049046 AT genotype showed a greater susceptibility to the burnout cynicism compared to AA homozygote only in medium-stress group (F = 4.327, df = 1,117, p = 0.015). The individuals who had lower sBDNF showed higher burnout level than those who had higher sBDNF in low-stress group. Conclusions: Our findings suggest that the BDNF system may interact with job stress to affect burnout, showing that interaction between BDNF rs2049046 and job stress or the interaction between BDNF levels with work stress on certain burnout dimensions. |
关键词 | Job stress Burnout Gene polymorphism sBDNF |
2020-04-01 | |
语种 | 英语 |
DOI | 10.1016/j.jad.2020.01.181 |
发表期刊 | JOURNAL OF AFFECTIVE DISORDERS |
ISSN | 0165-0327 |
卷号 | 266页码:671-677 |
期刊论文类型 | article |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China[81271491] ; National Natural Science Foundation of China[81571322] ; National Natural Science Foundation of China[81871060] |
出版者 | ELSEVIER |
WOS关键词 | NEUROTROPHIC FACTOR ; COGNITIVE IMPAIRMENT ; METHYLATION ; DEPRESSION ; DISORDER ; VAL66MET ; BIPOLAR ; PATHWAY ; AXIS |
WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
WOS类目 | Clinical Neurology ; Psychiatry |
WOS记录号 | WOS:000520892700087 |
Q分类 | Q1 |
资助机构 | National Natural Science Foundation of China |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/31525 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | He, Shu-Chang; Zhang, Xiang Yang |
作者单位 | 1.Peking Univ, Sch Psychol & Cognit Sci, 5 Yiheyuan Rd, Beijing 100871, Peoples R China 2.Peking Univ, Beijing Key Lab Behav & Mental Hlth, 5 Yiheyuan Rd, Beijing 100871, Peoples R China 3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | He, Shu-Chang,Wu, Shuang,Wang, Chao,et al. Interaction between job stress, serum BDNF level and the BDNF rs2049046 polymorphism in job burnout[J]. JOURNAL OF AFFECTIVE DISORDERS,2020,266:671-677. |
APA | He, Shu-Chang.,Wu, Shuang.,Wang, Chao.,Wang, Dong-Mei.,Wang, Jiesi.,...&Zhang, Xiang Yang.(2020).Interaction between job stress, serum BDNF level and the BDNF rs2049046 polymorphism in job burnout.JOURNAL OF AFFECTIVE DISORDERS,266,671-677. |
MLA | He, Shu-Chang,et al."Interaction between job stress, serum BDNF level and the BDNF rs2049046 polymorphism in job burnout".JOURNAL OF AFFECTIVE DISORDERS 266(2020):671-677. |
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